Charcot Marie Tooth Disease

In order to communicate information between boldness carrels, electrical signals are sent down long soreness pathways c tot totallyyed axons. To speed up the process of sending this information, the axon is insulated by myelin which is produced by another type of cell called the Schwann cell. (2, 6, 7) myeline twists around the axon and prevents the diversion of any electrical signal, render figure 1. Nerve cells are futile to turn on point muscles without an intact axon and myelin sheath. They are alike unable to resend sensory information from the limbs back to the brain.(2, 6) Charcot Marie Tooth disorder is caused by a summercater in the factors that make the protein responsible for the structure and/ or function of the axon and myelin sheath. In 1886, Professor denim Martin Charcot of France, see figure 2, and his student Pierre Marie published the limb description of distal muscle weakness in the legs and called it peroneal muscular atrophy. (13) Later, Henry Howard Henry Tooth attributed the symptoms described by Charcot and Marie to neuropathy which is a defect in the nerves. (13) Charcot Marie Tooth Disease is caused by a renewal within one of our elements and it can happen to any pagan group and affects 1 out of every 3, 300 sight worldwide.

(3) Mutations within our genes are inherited and each of us carries both(prenominal) copies of each gene, one from each parent. There are more than forms of Charcot Marie Tooth (CMT) affection; however, the one focused on for this research composition is CMT1A. (3, 6, 9) There are three main types of CMT1, which are all caused by abnormalities in the myelin sheath found on th e neurons of the peripheral nerves. CMT1A is! an autosomal dominant disease. An autosomal dominant disease means that only one copy of the abnormal gene is needed in order to have the disease. (2) CMT1A is caused by genomic bare(a) on chromosome 17, see figure 3. The Duplication is caused by an despicable meiotic crossover resulting from homologous sequences near the duplicated region....If you want to be in possession of a full essay, order it on our website: OrderEssay.net

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